Can we work out the fundamental questions of the universe?

There is nothing to say the more fundamental a question is the more difficult it is to workout.
What’s stopping up making that leap to work out the fundamental answers of the universe? It is intelligence, such as with Pierre de Fermat last theorem where it took us hundreds of years to work out and only then was done by a super computer? Or it is knowledge based in a sense. A modem microchip has been created off slight improvements off the last design, using the knowledge from the last advancement to make an ever more complex design.
Do the fundamental questions of the universe and answers have more steps to them to make it easier or do scientists have a wall to climb? Do scientists have more to work out in other fields gaining knowledge before tackling these questions head on?

What are your thoughts on this?

http://www.timesonline.co.uk/tol/news/science/article7149095.ece