Should the current regulations against smoking and illegal drugs be reversed in the US?

After the discussion about the lawsuit against McDonalds, there seemed to be a consensus that it’s not the government’s place to regulate advertise for the fast food industry and that it’s the parents’ responsibility.

So, I want to know, do you think the regulations on smoking, advertisement for smoking, and the regulations on illegal drugs like cocaine and marijuana should be lifted or challenged in the US? I know it’s different for other countries.