What in your opinion is the ultimate question?

Whats the big one? The greatest question there is. The one you have asked yourself many times, but cannot find an answer.
Is it personal? Or is it one for all of human kind?
Is it complicated, or simple? Maybe it is as simple as ‘why?’ or ‘why not?’
Do you feel it even has an answer? Or maybe more than one?
Think about it, and post your thoughts, rate others that you think are good and relevant and maybe together we can have a shot at those with the largest number of great answers.