Is keeping things shut down for the coronavirus more damaging physically and emotionally than opening them back up?

When the coronavirus was first identified as a problem and started hitting the US, the economy was effectively shutdown. Now there is an outcry to open it back up and there is a lot of differing opinions about that. A letter was written and signed by 600 physicians and sent to the WH asking the economy to be reopened for health reasons. They identify many aspects of the shutdown that result in many, many health issues. Additionally, Dr. Fauci is calling for the economy to be reopened. Reopening will likely cause an uptick in Covid-19 cases. Should we stay shutdown or reopen? And why?