What's the best route from Orange County to San Francisco?

5 it is

101?

I’d say the 5. Enjoy your music!

Go with The 5.

The 5 is fastest. The 101 is a much nicer drive, but it takes forever. I usually take the 5 to Pacheco Pass (152 Gilroy) to the 101. If you go that way you can stop at Casa De Fruta, where the cup flipper used to perform.
Have a nice trip, be safe :)

Just don’t stop anywhere near Harris Ranch!

mapquest.com and Rand mcnally.

The 5 is faster, but has fewer amenities and gas stations. The 101 is more scenic, but becomes a parking lot as it passes through coastal towns.

or roll down the windows, am I right tinyfaery?

Go North… Turn left… If you hit water you went to far….

We used to go straight up the 101.